BDBM282805 6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol- 5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile::US10287295, Example 14'::US11352360, Example 14'::US9884868, Example 14'

SMILES OCCn1cnc(c1-c1ccc2ncc(C#N)n2n1)-c1ccc(F)cc1

InChI Key InChIKey=AIQZOKCURJAIIL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 282805   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  5.30nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  5.30nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  350nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  5.30nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  800nMAssay Description:Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of wild type His-tagged TGFBR2 kinase domain (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed