BDBM282824 6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)methyl)- 1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3- carbonitrile::US10287295, Example 31'::US11352360, Example 31'::US9884868, Example 31'

SMILES Fc1ccc(cc1)-c1ncn(CC2CCCO2)c1-c1ccc2ncc(C#N)n2n1

InChI Key InChIKey=FQLIEQVGWILNSI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 282824   

TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  1.90nMpH: 7.4 T: 2°CAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  3.71E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  3.71E+3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-2(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  3.71E+3nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  1.90nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTGF-beta receptor type-1 [T204D](Homo sapiens (Human))
Rigel Pharmaceuticals

US Patent
LigandPNGBDBM282824(6-(4-(4-fluorophenyl)-1-((tetrahydrofuran-2-yl)met...)
Affinity DataIC50:  1.90nMAssay Description:Assays for the compounds reported below were conducted in 1536-well plates and 2 mL reactions are prepared from addition of HIS-TGF-βR1 T204D or...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent