BDBM285659 US10077273, Compound 68::US10584132, Compound 68::US10934305, Compound 68
SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(cc(c1)C#CCCC(O)=O)C#N
InChI Key
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 285659
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
Affinity DataIC50: 0.400nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
Affinity DataIC50: 1.70nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
Affinity DataIC50: 1.70nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
Affinity DataIC50: 0.400nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
TargetSerine hydroxymethyltransferase, mitochondrial(Human)
The Trustees of Princeton University
US Patent
The Trustees of Princeton University
US Patent
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair