BDBM285667 US10077273, Compound 73::US10584132, Compound 73::US10934305, Compound 73

SMILES COC(=O)CCC#Cc1cc(cc(c1)C1(C(C)C)c2c(C)n[nH]c2OC(N)=C1C#N)C(F)(F)F

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 285667   

TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285667(US10077273, Compound 73 | US10584132, Compound 73 ...)
Affinity DataIC50:  7.5nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285667(US10077273, Compound 73 | US10584132, Compound 73 ...)
Affinity DataIC50:  7.5nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285667(US10077273, Compound 73 | US10584132, Compound 73 ...)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of human SHMT by compounds in this disclosure is evaluated, for example, in their racemic forms in an in vitro assay. For example, Compoun...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent