BDBM285684 US10077273, Compound HK-14::US10934305, Compound HK-14

SMILES CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(Cl)cc(Cl)c1

InChI Key

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 285684   

TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285684(US10077273, Compound HK-14 | US10934305, Compound ...)
Affinity DataIC50:  131nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, mitochondrial(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285684(US10077273, Compound HK-14 | US10934305, Compound ...)
Affinity DataIC50:  67nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285684(US10077273, Compound HK-14 | US10934305, Compound ...)
Affinity DataIC50:  131nMAssay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine hydroxymethyltransferase, cytosolic(Homo sapiens (Human))
The Trustees of Princeton University

US Patent
LigandPNGBDBM285684(US10077273, Compound HK-14 | US10934305, Compound ...)
Affinity DataIC50:  67nMpH: 7.4Assay Description:For the SHMT1 and SHMT2 in vitro enzymatic assays, the rate of 5,10-methylene tetrahydrofolate formation catalyzed by SHMT1/2 was indirectly evaluate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent