BDBM285694 US10077289, Compound 3::[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)-5-(1-(N-pyrrolidinyl-ethyl)-1H-imidazol-2-yl) pentanoic acid]1 [(R)-methyl-Sar]3 cyclosporin A
SMILES CC[C@H]1NC(=O)[C@@H]([C@H](O)[C@H](C)Cc2nccn2CCN2CCCC2)N(C)C(=O)[C@@H](C(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)NC(=O)[C@@H](CC(C)C)N(C)C(=O)[C@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)N(C)C1=O)C(C)C
InChI Key InChIKey=AJEVDDMWVCXOLF-QWNMPOMASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 285694
Affinity DataKi: 8.60nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
TargetSerine/threonine-protein phosphatase 2B catalytic subunit gamma isoform(Homo sapiens (Human))
Allergan
US Patent
Allergan
US Patent
Affinity DataIC50: 1.00E+4nMAssay Description:Enzo Life Sciences CaN Assay Kit: BML-AK8042x assay buffer: 100 mM Tris, pH7.5, 200 mM NaCl, 12 mM MgCl2, 1 mM DTT, 0.05% NP-40, 1 mM CaCl2More data for this Ligand-Target Pair