BDBM288259 5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-::US10087185, Example 109::US10087185, Example 77

SMILES Cc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C(F)(F)F

InChI Key InChIKey=NNAPSWBSSLZNIM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 288259   

TargetVoltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288259(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...)
Affinity DataIC50:  0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent calcium channel gamma-8 subunit(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM288259(5-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-8-...)
Affinity DataIC50:  0.251nMpH: 7.4Assay Description:This assay was used to test compounds for their ability to inhibit TARP γ8 dependent AMPA receptor activity. The AMPA receptor is a non-selectiv...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent