BDBM29026 CHEMBL142996::cyanocyclopropylpropenamide, 11

SMILES O=C(Nc1ccc(cc1)-c1ccccc1)C(C#N)C(=O)C1CC1

InChI Key InChIKey=DIIHYLMEQKHUBY-UHFFFAOYSA-N

Data  2 KI  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 29026   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
University of Leeds

LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataKi:  7nM IC50:  53nMAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Leeds

LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataKi:  2.60E+4nM ΔG°:  -6.25kcal/mole IC50:  2.24E+5nMpH: 8.0 T: 2°CAssay Description:The assays were carried out by using a colorimetric DCIP method, which uses the colorimetric reagent 2, 6-dichlorophenolindophenol as the final elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataIC50:  1.48E+3nMAssay Description:Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in ratMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
Hoechst Marion Roussel

Curated by ChEMBL
LigandPNGBDBM29026(CHEMBL142996 | cyanocyclopropylpropenamide, 11)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouseMore data for this Ligand-Target Pair