BDBM292422 (S)-(2-(aminomethyl)-4,4-difluoropyrrolidin-1-yl)(2-(5-(thiophen-2-yl)pyrazolo[1,5-a]pyrimidin-3-yl)pyridin-4-yl)methanone::US10100058, Example 78

SMILES NC[C@H]1CC(F)(F)CN1C(=O)c1ccnc(c1)-c1cnn2ccc(nc12)-c1cccs1

InChI Key InChIKey=GMBVMBJWDMLLKP-CQSZACIVSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 292422   

TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM292422((S)-(2-(aminomethyl)-4,4-difluoropyrrolidin-1-yl)(...)
Affinity DataEC50:  316nMAssay Description:CaMKII activity in neonatal rat ventricular myocytes (NRVM) was measured by monitoring the phosphorylation level of phospholamban using high-content ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcium/calmodulin-dependent protein kinase type II subunit delta(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM292422((S)-(2-(aminomethyl)-4,4-difluoropyrrolidin-1-yl)(...)
Affinity DataIC50:  9.44nMAssay Description:The biochemical activity of recombinant CaMKIIδ was measured by monitoring the phosphorylation of a target peptide using Homogenous Time Resolve...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent