BDBM29313 dithioether 1,3,4-thiadiazole, 8f

SMILES [O-][N+](=O)c1cnc(Sc2nnc(Sc3ncc(s3)[N+]([O-])=O)s2)s1

InChI Key InChIKey=QYKQHNTWQJPQOZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 29313   

TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM29313(dithioether 1,3,4-thiadiazole, 8f)
Affinity DataIC50:  800nMAssay Description:Compounds were tested for their ability to inhibit JNK1 phosphorylation of ATF2 in the Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM29313(dithioether 1,3,4-thiadiazole, 8f)
Affinity DataIC50:  187nMAssay Description:Compound was evaluated for its ability to disrupt the interaction of pepJIP1 with JNK1 by using DELFIA assay. DELFIA is a heterogeneous assay whereby...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed