BDBM295666 (S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazolidin-3-yl)-5,6- dihydrobenzo[f]imidazo[1,2- d][1,4]oxazepin-9- yl)amino)acetamide::US10112932, Compound 102::US10851091, Compound 102

SMILES C[C@@H]1COC(=O)N1c1cn2CCOc3cc(N[C@@H](C4CCC4)C(N)=O)ccc3-c2n1

InChI Key InChIKey=XJWQCIXSLCHRNE-XIKOKIGWSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 295666   

LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  0.949nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  0.949nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  286nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  286nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  708nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi:  708nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphatidylinositol 3-kinase regulatory subunit beta(Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi: >1.00E+3nMAssay Description:PI3K Binding assays are intended for determining the biochemical potency of small molecule PI3K inhibitors. The PI3K lipid kinase reaction is perform...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM295666((S)-2-cyclobutyl-2-((2-((R)-4- methyl-2-oxooxazoli...)
Affinity DataKi: >1.00E+3nMAssay Description:The biochemical inhibition of four PI3K isoforms by the Formula I compounds of Table 1. In addition, two clinically tested PI3K compounds, taselisib ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent