BDBM29879 alkynyl ether, 21

SMILES CCC#CCOc1cc(COc2ccc(cc2)C(F)(F)F)ccc1Sc1ccc(OCC(O)=O)c2CCCCc12

InChI Key InChIKey=SIHDSSYICQEWRS-UHFFFAOYSA-N

Data  3 KI  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 29879   

TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Amgen

LigandPNGBDBM29879(alkynyl ether, 21)
Affinity DataKi:  5nM EC50:  44nMAssay Description:The human PPARdelta ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Amgen

LigandPNGBDBM29879(alkynyl ether, 21)
Affinity DataKi:  33nM EC50:  160nMAssay Description:The human PPARgamma ligand binding was directly measured using a filtration assay in a UniFilter 350 96-well assay plate (Polyfiltronics). The reacti...More data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Amgen

LigandPNGBDBM29879(alkynyl ether, 21)
Affinity DataKi:  880nM ΔG°:  -8.17kcal/mole EC50: >1.00E+5nMpH: 7.1 T: 2°CAssay Description:The human PPARalpha ligand binding was directly measured using a scintillation proximity assay. Plates were read on a Packard TopCount. IC50 values f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed