BDBM299136 (6S,8R)-7-(2,2- difluoropropyl)-6- (2-fluoro-4-(2-(3- (fluoromethyl) azetidin-1- yl)ethoxy)-6- methoxyphenyl)- 8-methyl-6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 25

SMILES COc1cc(OCCN2CC(CF)C2)cc(F)c1[C@H]1N(CC(C)(F)F)[C@H](C)Cc2c1ccc1[nH]ncc21

InChI Key

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 299136   

TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM299136((6S,8R)-7-(2,2- difluoropropyl)-6- (2-fluoro-4-(2-...)
Affinity DataIC50:  1.30nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent