BDBM299145 (6S,8R)-6-(2,6- difluoro-4-(2-(3- (fluoromethyl) azetidin-1- yl)ethoxy) phenyl)-7-(2,3- difluoropropyl)- 8-methyl- 6,7,8,9- tetrahydro-3H- pyrazolo[4,3- f]isoquinoline::US10125135, Example 34::US10125135, Example 35

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)CF)c1c(F)cc(OCCN2CC(CF)C2)cc1F

InChI Key

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 299145   

TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM299145((6S,8R)-6-(2,6- difluoro-4-(2-(3- (fluoromethyl) a...)
Affinity DataIC50:  2.70nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEstrogen receptor(Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM299145((6S,8R)-6-(2,6- difluoro-4-(2-(3- (fluoromethyl) a...)
Affinity DataIC50:  3.80nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent