BDBM300056 N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- methoxypropan-2- yl]oxy}-6-[4-(4- methoxy-1H- pyrrolo[2,3- b]pyridin-3- yl)piperidin-1- yl]pyrimidine-4- carboxamide::US9593097, Example 436::US9593097, Example 437::US9593097, Example 495::US9593097, Example 498::US9593097, Example 499

SMILES COC[C@@H](C)Oc1nc(cc(n1)C(=O)NC(C)C(C)(C)N)N1CCC(CC1)c1c[nH]c2nccc(OC)c12

InChI Key

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 300056   

TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer Inc

US Patent
LigandPNGBDBM300056(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Affinity DataKi:  0.0340nMAssay Description:AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer Inc

US Patent
LigandPNGBDBM300056(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Affinity DataKi:  0.0880nMAssay Description:AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer Inc

US Patent
LigandPNGBDBM300056(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Affinity DataKi:  1.59nMAssay Description:AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer Inc

US Patent
LigandPNGBDBM300056(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Affinity DataKi:  2.80nMAssay Description:AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
Pfizer Inc

US Patent
LigandPNGBDBM300056(N-(3-amino-3- methylbutan-2-yl)- 2-{[(2R)-1- metho...)
Affinity DataKi:  8.42nMAssay Description:AXL enzyme inhibition (% inhibition, Kiapp and Ki values) by small molecule inhibitors was evaluated using a fluorescence-based microfluidic mobility...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent