BDBM3033 3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^{11,15}.0^{17,22}]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-3-yl}propanenitrile::CHEMBL302449::Go 6976::Indolocarbazole deriv.

SMILES Cn1c2ccccc2c2c3C(=O)NCc3c3c4ccccc4n(CCC#N)c3c12

InChI Key InChIKey=VWVYILCFSYNJHF-UHFFFAOYSA-N

Data  5 KI  25 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 3033   

TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of human PLK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Entremed

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi:  3.40nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi: >8.00E+3nM ΔG°: >-6.88kcal/molepH: 7.5 T: 2°CAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK3(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi: >1.60E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK2(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataKi: >1.90E+4nMAssay Description:Kinase was assayed in 384-well polypropylene plate format. The compound was mixed with kinase and biotinylated peptide substrate and incubated. After...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCalphaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of PKCalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  27nMAssay Description:Inhibition of PKD1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of PKCalpha by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase D1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  62nMAssay Description:Inhibition of PKD1 assessed as HDAC5 neuclear exportMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Albert-Ludwigs-University Of Freiburg

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human recombinant SIRT2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PKCbeta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  5.80E+3nMAssay Description:In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  6.20E+3nMAssay Description:In vitro for inhibitory activity against cGMP-dependent protein kinase from bovine lung (G-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro for inhibitory activity against cAMP-dependent protein kinase from bovine heart (A-kinase)More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  446nMAssay Description:Inhibition of PKCdelta by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C gamma type(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCgammaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCbetaChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  20nMAssay Description:In vitro for inhibitory activity against protein kinase C from rat brainMore data for this Ligand-Target Pair
In DepthDetails Article
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Tumor Biology Center

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  5.80E+3nMAssay Description:Tested for inhibition of Myosin light chain kinase from chicken gizzardMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase Blk(Mus musculus)
Tumor Biology Center

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: >1.00E+4nMAssay Description:Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysateMore data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  67nMAssay Description:Inhibition of JAK2 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))TBA
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))TBA
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  118nMAssay Description:Inhibition of Aurora-A (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Mus musculus (mouse))
Tumor Biology Center

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: >1.00E+4nMAssay Description:The activity of TPK is measured by its ability to transfer 32P from [gamma-32P]ATP to Poly(Glu,Tyr; 4:l).More data for this Ligand-Target Pair
In DepthDetails Article
TargetcGMP-dependent protein kinase 1(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  6.20E+3nMAssay Description:The activity of cGPK, activated by cGMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetcAMP-dependent protein kinase catalytic subunit alpha(Bos taurus (bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50: >1.00E+5nMAssay Description:The activity of PKA, activated by cAMP, is measured by its ability to transfer phosphate from [gamma-32P]ATP to histone.More data for this Ligand-Target Pair
In DepthDetails Article
TargetProtein kinase C beta type(Rattus norvegicus (rat))
Tumor Biology Center

LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  20nMAssay Description:The activity of PKC, activated by phosphatidylserine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich hi...More data for this Ligand-Target Pair
In DepthDetails Article
TargetAurora kinase B(Homo sapiens (Human))TBA
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  78nMAssay Description:Inhibition of Aurora-B (unknown origin) by kinase-glo luminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMyosin light chain kinase, smooth muscle(Gallus gallus (chicken))
TBA

Curated by ChEMBL
LigandPNGBDBM3033(3-{23-methyl-14-oxo-3,13,23-triazahexacyclo[14.7.0...)
Affinity DataIC50:  5.80E+3nMpH: 7.2 T: 2°CAssay Description:The activity of MLCK is measured by its ability to transfer 32P from [gamma-32P]ATP to myosin light-chain.More data for this Ligand-Target Pair
In DepthDetails Article