BDBM304055 4-[5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-ylmethoxy]-2-(3,3,3-trifluoro-2-hydroxypropyl)-2,3-dihydro[1,2,4]triazolo[4,3-a]pyridin-6-yl]benzonitrile::US10138249, Example 12::US9758523, Example 12

SMILES Cc1ccc(cc1)-c1c(cc(OC[C@@H]2CCNC2)c2nn(CC(O)C(F)(F)F)c(=O)n12)-c1ccc(cc1)C#N

InChI Key InChIKey=DQRBVSZZPVKMLV-PHSANKKPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 304055   

TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM304055(4-[5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Affinity DataIC50:  75nMAssay Description:LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Incyte

US Patent
LigandPNGBDBM304055(4-[5-(4-methylphenyl)-3-oxo-8-[(3R)-pyrrolidin-3-y...)
Affinity DataIC50:  75nMAssay Description:LANCE LSD1/KDM1A demethylase assay-10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent