BDBM307577 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)-4- (isoquinolin-1-ylamino)-2-methylpyrrolidin- 1-yl)methanone::US10150751, Example 12

SMILES C[C@@H]1C[C@H](CN1C(=O)c1ccccc1-n1nccn1)Nc1nccc2ccccc12

InChI Key InChIKey=LDRXLAMNOJZDSW-SJLPKXTDSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307577   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307577((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)-4- (isoq...)
Affinity DataIC50:  257nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307577((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)-4- (isoq...)
Affinity DataIC50:  15.3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent