BDBM307583 2-(((3R,5R)-1-(2-(2H-1,2,3-triazol-2- yl)benzoyl)-5-methylpyrrolidin-3- yl)amino)isonicotinonitrile::US10150751, Example 19

SMILES C[C@@H]1C[C@H](CN1C(=O)c1ccccc1-n1nccn1)Nc1cc(ccn1)C#N

InChI Key InChIKey=VNRGSEPNAFPAPI-GDBMZVCRSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307583   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307583(2-(((3R,5R)-1-(2-(2H-1,2,3-triazol-2- yl)benzoyl)-...)
Affinity DataIC50: >1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307583(2-(((3R,5R)-1-(2-(2H-1,2,3-triazol-2- yl)benzoyl)-...)
Affinity DataIC50:  22.9nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent