BDBM307585 (2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)- 4-((4-ethoxypyridin-2-yl)amino)-2- methylpyrrolidin-1-yl)methanone::US10150751, Example 21

SMILES CCOc1ccnc(N[C@@H]2C[C@@H](C)N(C2)C(=O)c2ccccc2-n2nccn2)c1

InChI Key InChIKey=IOMONLAGLRBQRM-HZPDHXFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307585   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307585((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)- 4-((4-e...)
Affinity DataIC50:  3.99E+3nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307585((2-(2H-1,2,3-triazol-2-yl)phenyl)((2R,4R)- 4-((4-e...)
Affinity DataIC50:  31.5nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent