BDBM307602 ((2R,4R)-4-((3-Methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(3- (4-methyl-1H-pyrazol-1-yl)pyridin-2- yl)methanone::US10150751, Example 41

SMILES COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1cccnc1-n1cc(C)cn1

InChI Key InChIKey=ZBTATRPRQPLTPX-HZPDHXFCSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307602   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307602(((2R,4R)-4-((3-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307602(((2R,4R)-4-((3-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  758nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent