BDBM307606 ((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methylpyrrolidin-1-yl)(2- (3-methyl-1,2,4-oxadiazol-5- yl)phenyl)methanone::US10150751, Example 45

SMILES COc1cccnc1N[C@@H]1C[C@@H](C)N(C1)C(=O)c1ccccc1-c1nc(C)no1

InChI Key InChIKey=YTQVSRRLGAYXMZ-UKRRQHHQSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 307606   

TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307606(((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  1.00E+4nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM307606(((2R,4R)-4-((4-Methoxypyridin-2- yl)amino)-2-methy...)
Affinity DataIC50:  278nMAssay Description: All reagents were from GIBCO-Invitrogen Corp. The seeded plates are incubated overnight at 37° C. and 5% CO2. Ala-6,12 human orexin-A as the agonist...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent