BDBM307708 4''-fluoro-6'-(3-fluoropropoxy)-4-[(2H3)methyloxy]-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-pyrrol]-5''-amine::US9650336, Example 11

SMILES COC1CC[C@]2(Cc3ccc(OCCCF)cc3C22C=C(F)C(N)=N2)CC1

InChI Key InChIKey=CDBDNOAMUOHDPM-SDLRAYFESA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 307708   

TargetBeta-secretase 1 [1-460](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM307708(4''-fluoro-6'-(3-fluoropropoxy)-4-[(2H3)methyloxy]...)
Affinity DataIC50:  1.22E+3nMAssay Description:The cDNA for the soluble part of the human 13-Secretase (AA 1-AA 460) was cloned using the ASP2-Fc10-1-IRES-GFP-neoK mammalian expression vector. The...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent