BDBM311267 (S)-1-((2′,6-bis(difluoromethyl)-[2,4′-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine::US10155760, Example 123::US10351563, Example 123::US10544120, Example 123::US10723734, Example 123::US10981910, Example 123::US9902722, Example 123

SMILES CC(C)C[C@](C)(N)COc1ccc(nc1C(F)F)-c1ccnc(c1)C(F)F

InChI Key InChIKey=RKAHOQATMSONTM-IBGZPJMESA-N

Data  37 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 311267   

TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length human AAK1 expressed in HEK293F cells assessed as suppression of AP2 phosphorylation measured after 3 hrs by Western blot a...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 Cl prepared from 15 μl additions of enzyme and substrates (...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of GST-Xa tagged human AAK1 (30 to 330 residues) expresssed in bacteria using (5-FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of AKK1 in HEK293F cells assessed as reduction in phospho mu2 formation incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin) using BFC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP2B6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using BSF as substrate measured at 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >2.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using BSF as substrate measured at 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using MDZ as substrate measured at 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using TST as substrate measured at 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier organic anion transporter family member 1B3(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/bile acid cotransporter(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of NTCP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile salt export pump(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of BSEP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of MRP2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 6(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OAT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 22 member 8(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of OAT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of BCRP (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  390nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of BIKE (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  800nMAssay Description:Inhibition of GAK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCitron Rho-interacting kinase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  410nMAssay Description:Inhibition of CRIK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LATS2(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  660nMAssay Description:Inhibition of LATS2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  160nMAssay Description:Inhibition of MNK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using MDZ as substrate measured at 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50: >4.00E+4nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) using TST as substrate measured at 5 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2nMAssay Description:Inhibition of bacterially expressed GST-Xa-tagged human AAK1 using 5-FAM-labelled Aha-KEEQSQITSQVTGQIGWR-NH2 peptide as substrate incubated for 3 hrs...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAP2-associated protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM311267((S)-1-((2′,6-bis(difluoromethyl)-[2,4′...)
Affinity DataIC50:  2.20nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μl prepared from 15 μl additions of enzyme and substra...More data for this Ligand-Target Pair
In DepthDetails US Patent