BDBM31172 3-hydroxyquinolin-2(1H)-one, 26

SMILES Oc1cc2c(Cl)c(F)ccc2[nH]c1=O

InChI Key InChIKey=SJNYFCFQCNCHDD-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 31172   

TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50:  5nMpH: 8.5 T: 2°CAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: >4.32E+4nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-aspartic acid was linke...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Rattus norvegicus (rat))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50:  50nMAssay Description:Inhibitory effect of compounds was determined in a cell free fluorescence assay. The H2O2 generated from the degradation of D-serine was linked to ox...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-aspartate oxidase(Bos taurus)
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataKd:  5.5nMAssay Description:Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataKd:  4.60nMAssay Description:Binding affinity to human recombinant DAAO by steady state study scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Abbott Healthcare Products

Curated by ChEMBL
LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD-amino-acid oxidase(Homo sapiens (Human))
Pfizer

LigandPNGBDBM31172(3-hydroxyquinolin-2(1H)-one, 26)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed