BDBM31802 Apogossypol::US9115061, Apogossypol

SMILES CC(C)c1c(O)c(O)cc2c(O)c(c(C)cc12)-c1c(C)cc2c(C(C)C)c(O)c(O)cc2c1O

InChI Key InChIKey=PBJKWGWHZVXBGU-UHFFFAOYSA-N

Data  4 KI  5 IC50  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31802   

TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50:  3.69E+3nMT: 2°CAssay Description:A Bak BH3 peptide (F-BakBH3) (GQVGRQLAIIGDDINR) was labeled at the N-terminus with fluorescein isothiocyanate (FITC) (Molecular Probes) and purified ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBcl-2-related protein A1(Homo sapiens (Human))
Burnham Institute For Medical Research

LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50:  2.60E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50:  4.30E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM31802(Apogossypol | US9115061, Apogossypol)
Affinity DataIC50:  3.70E+3nM Kd:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:FPAs were performed using various concentrations of GST-Bcl-2 family proteins, incubated with FITC-conjugated peptide substrates in the presence of i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed