BDBM31980 Dipeptidyl nitrile inhibitor, 13

SMILES Cc1cc(C)cc(c1)C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)NCC#N

InChI Key InChIKey=XGRUEGXUKKXMFE-SFHVURJKSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 31980   

TargetProcathepsin L [114-333,T223A](Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50:  50nMpH: 7.0 T: 2°CAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin L2(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50:  200nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50:  7.94E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50:  5.01E+3nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin S(Homo sapiens (Human))
Astrazeneca

LigandPNGBDBM31980(Dipeptidyl nitrile inhibitor, 13)
Affinity DataIC50:  316nMAssay Description:IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed