BDBM320642 (S)-3-(Fluoromethyl)-6-hydroxy-1- (1-(4- (pentafluorolhio)phenyl)ethyl)-1H- pyrazolo[3,4-d]pyrimidin-4(5H)- one::US10174037, Example 50
SMILES C[C@@H](c1ccc(cc1)C(F)(F)F)n1nc(CF)c2c1nc(O)[nH]c2=O
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 320642
Affinity DataKi: 6.80nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme
US Patent
Merck Sharp & Dohme
US Patent
Affinity DataKi: 7nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Homo sapiens (Human))
Merck
Curated by ChEMBL
Merck
Curated by ChEMBL
Affinity DataIC50: 899nMAssay Description:Inhibition of human GST-tagged PDE9A2 expressed in insect cells using FAM-labeled cGMP as substrate incubated for 60 mins measured after 1 hr by IMAP...More data for this Ligand-Target Pair