BDBM321348 3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-1-yl]-methyl} amino)pyridine-4-carboxylic acid::US10179769, Example 62::US10807956, Example 62::US11214542, Example 62::US11639333, Example 62

SMILES COc1ccc2[C@H](CNc3cnccc3C(O)=O)CCCc2c1

InChI Key InChIKey=NXQKMWGCRMQRSS-ZDUSSCGKSA-N

Data  3 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 321348   

TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM321348(3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...)
Affinity DataIC50:  550nMAssay Description:The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM321348(3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...)
Affinity DataIC50:  550nMAssay Description:JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM321348(3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of KDM4C (unknown origin) using biotinylated H3K9me3 peptide and alpha-ketoglutarate as substrate pretreated for 1 hr followed by substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 4C(Homo sapiens (Human))
Celgene Quanticel Research

US Patent
LigandPNGBDBM321348(3-({[(1R)-6-methoxy-1,2,3,4- tetrahydronaphthalen-...)
Affinity DataEC50:  560nMAssay Description:Inhibition of full-length KDM4C (unknown origin) expressed in human KYSE-150 cells assessed as increase in H3K36me3 level after 24 hrs by Western blo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed