BDBM32142 5-amino-8-quinolinol::5-aminoquinolin-8-ol::5-azanylquinolin-8-ol::AS-0308-225::cid_416002

SMILES Nc1ccc(O)c2ncccc12

InChI Key InChIKey=YDEUKNRKEYICTH-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 32142   

TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  2.76E+4nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of IDO1 in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50: >5.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50: >1.00E+4nMAssay Description:Emory Chemistry-Biology Discovery Center Assay Overview: MLSCN Grant: 1 X01MH78953-01 Hsp90 is a chaperon with important roles in maintaining transfo...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human UTMC2 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMH11 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KMS18 cells assessed as free 7-amino...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human OCI-AML2 cells assessed as free 7-am...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human NB4 cells assessed as free 7-amino-4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human KG1A cells assessed as free 7-amino-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human MDAY-D2 cells assessed as free 7-ami...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProteasome subunit beta type-5(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  600nMAssay Description:Inhibition of human 20S proteasome chymotryptic-like activity using Suc-LLVY-AMC as substrate expressed in human K562 cells assessed as free 7-amino-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Mus musculus)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of mouse recombinant TDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))TBA
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of human recombinant IDO expressed in Escherichia coli BL21 AIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Mus musculus)
Institute For Cancer Research

Curated by ChEMBL
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM32142(5-amino-8-quinolinol | 5-aminoquinolin-8-ol | 5-az...)
Affinity DataIC50:  1.56E+3nMpH: 7.4 T: 2°CAssay Description:A fluorescence polarization based HTS assay has been developed and optimized for the identification of Hsp90 inhibitors by using tumor cell lysate Hs...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay