BDBM321464 6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzimidazol-5-yl]-1H-pyrrolo[2,3-c]pyridin-7-one::US10183009, Example 56

SMILES C=CCCn1cc(-c2cc(C(=O)N3CCOCC3)c3nc[nH]c3c2)c2cc[nH]c2c1=O

InChI Key InChIKey=PGRPAJVQVRBFEA-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 321464   

TargetChromatin remodeling regulator CECR2 [424-538](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  21nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  16nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  820nMAssay Description:Inhibition of recombinant His-tagged CECR2 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 9(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of recombinant His-tagged BRD9 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of recombinant His-tagged BRD4 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscription initiation factor TFIID subunit 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM321464(6-but-3-enyl-4-[7-(morpholine-4-carbonyl)-3H-benzi...)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of recombinant His-tagged TAF1 bromodomain 1 (unknown origin) after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed