BDBM323750 3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}benzoic acid::US10189788, Example 30

SMILES Cc1c(nc2ccc(I)cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)-c1ccccc1

InChI Key InChIKey=FHXCMTABGWGXJA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 323750   

TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323750(3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-y...)
Affinity DataIC50:  6nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323750(3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-y...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM323750(3-Fluoro-4-{[(6-iodo-3-methyl-2-phenylquinolin-4-y...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed