BDBM323781 4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)carbonyl]amino}-3-fluorobenzoic acid::US10189788, Example 61

SMILES Cc1c(nc2ccc(cc2c1C(=O)Nc1ccc(cc1F)C(O)=O)C(C)(C)C)-c1ccccc1

InChI Key InChIKey=OCYFYABJSPCSCT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 323781   

TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323781(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Affinity DataIC50:  131nMAssay Description:For the characterization of test substances in respect of FP antagonism, PGF2α-induced calcium flux in FP-expressing CHEM1 cells (Millipore, HTS...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323781(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Affinity DataIC50:  130nMAssay Description:Antagonist activity at human FPR expressed in human Chem-1 cells assessed as inhibition of PGF2alpha-induced calcium flux preincubated for 10 mins fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM323781(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins in presence of NADPH generating system by LC-MS/MS ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin F2-alpha receptor(Homo sapiens (Human))
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM323781(4-{[(6-tert-Butyl-3-methyl-2-phenylquinolin-4-yl)c...)
Affinity DataIC50:  79nMAssay Description:For the characterization of test substances in respect of FP antagonism, the PGF2α-induced calcium flux in recombinant FP-expressing CHO cells w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent