BDBM32755 2-thiophenecarboxylic acid [5-amino-1-(4-methylphenyl)sulfonyl-3-pyrazolyl] ester::CHEMBL245264::MLS000033863::SMR000014914::Thiophene-2-carboxylic acid 5-amino-1-(toluene-4-sulfonyl)-1H-pyrazol-3-yl ester::[5-amino-1-(4-methylphenyl)sulfonylpyrazol-3-yl] thiophene-2-carboxylate::[5-azanyl-1-(4-methylphenyl)sulfonyl-pyrazol-3-yl] thiophene-2-carboxylate::cid_646525::thiophene-2-carboxylic acid (5-amino-1-tosyl-pyrazol-3-yl) ester

SMILES Cc1ccc(cc1)S(=O)(=O)n1nc(OC(=O)c2cccs2)cc1N

InChI Key InChIKey=NNWCFVBOMNJREB-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 32755   

TargetCathepsin B(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  1.99E+3nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCoagulation factor XI(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  2.62E+3nMpH: 7.4 T: 2°CAssay Description:Factor XIa (0.23 ug/mL) was incubated with Boc-Glu-Ala-Arg-AMC substrate (15 uM) in 10 uL of assay buffer for 2 hr at room temperature. Read fluoresc...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin B(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  2.83E+3nMAssay Description:Human liver cathepsin B (EC 3.4.22.1) is a lysosomal cysteine protease. There has been a recent resurgence of interest in cathepsin B due to research...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetComplement C1s subcomponent(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50: >5.00E+4nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Dr. Scott L. Diamond, University of Pen...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin B(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  1.99E+3nMAssay Description:Inhibition of human liver cathepsin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(West Nile virus)
University of Pittsburgh

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  2.41E+3nMAssay Description:The HTS assay to identify Inhibitors of West Nile Virus (WNV) NS2bNS3 Proteinase was proposed by Dr Alex Strongin of the Burnham Institute XO1-MH0776...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin G(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  8.07E+3nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetProcathepsin L(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50: >5.00E+4nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetKallikrein-5(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  7.44E+3nMAssay Description:Molecular Library Screening Center Network (MLSCN) Penn Center for Molecular Discovery (PCMD) Assay Provider: Scott L. Diamond, University of Pennsy...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCathepsin B(Homo sapiens (Human))
Pcmd

Curated by PubChem BioAssay
LigandPNGBDBM32755(2-thiophenecarboxylic acid [5-amino-1-(4-methylphe...)
Affinity DataIC50:  1.99E+3nMAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay