BDBM328997 1137478-45-5::US11787792, Compound Y-152::US9663503, Compound Y-152

SMILES Cn1cc(cn1)-c1cnc(Nc2cnc(cn2)C#N)cc1NC[C@@H]1CNCCO1

InChI Key InChIKey=HGYKCQUYMKJVQI-HNNXBMFYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 328997   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  2nMAssay Description:CHK1 kinase activity was measured in a microfluidic assay that monitors the separation of a phosphorylated product from its substrate. The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  2.20E+4nMAssay Description:Displacement of [3H]astemizole from human ERG expressed in HEK293 cells by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM328997(1137478-45-5 | US11787792, Compound Y-152 | US9663...)
Affinity DataIC50:  400nMAssay Description:Inhibition of CHK1 in human HT-29 cells assessed as abrogation of etoposide-induced G2 checkpoint arrest by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed