BDBM329423 2-((1S,2S)-2-((2- methyl-5-m- tolylpyrimidin-4- yloxy)methyl)cyclopropyl) quinoline (enantiomer A)::US9663513, 36::US9663513, 37

SMILES Cc1cccc(c1)-c1cnc(C)nc1OC[C@H]1C[C@@H]1c1ccc2ccccc2n1

InChI Key InChIKey=KMFFHWNEXFOXCB-RTWAWAEBSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 329423   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329423(2-((1S,2S)-2-((2- methyl-5-m- tolylpyrimidin-4- yl...)
Affinity DataKi:  0.0900nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329423(2-((1S,2S)-2-((2- methyl-5-m- tolylpyrimidin-4- yl...)
Affinity DataKi:  7.24nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent