BDBM329551 1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b]pyridin-2- yl)cyclopropyl)methoxy)- 2-methylpyrimidin-5-yl)- 1-methyl-1H-pyrazol-3- yl)ethanol(enantiomer A, R or S)::US9663513, 164::US9663513, 165::US9663513, 166::US9663513, 167

SMILES CC(O)c1nn(C)cc1-c1cnc(C)nc1OC[C@@H]1C[C@H]1c1ccc2CCCc2n1

InChI Key InChIKey=AKELEHXXIQFOQF-ZMKYACIDSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 329551   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329551(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Affinity DataKi:  0.0400nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329551(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Affinity DataKi:  0.0500nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329551(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Affinity DataKi:  5.44nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM329551(1-(4-(4-(((1R,2R)-2-(6,7- dihydro-5H- cyclopenta[b...)
Affinity DataKi:  8.11nMAssay Description:The fluorescence polarization assay for cyclic nucleotide phosphodiesterases was performed using an IMAP® FP kit supplied by Molecular Devices, Sunny...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent