BDBM331518 2-{8-[(3-Fluoropyridin-2-yl)(oxan-4-yl)methyl]-11-[4-(2H3)methyl-1-methyl-1H-1,2,3-triazol-5-yl]-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2,4,6,10,12-hexaen-5-yl}propan-2-ol::US9725449, Example 362::US9725449, Example 363

SMILES Cc1n[nH]n(C)c1-c1ccc2c3cnc(cc3n(C(C3CCOCC3)c3ncccc3F)c2n1)C(C)(C)O

InChI Key InChIKey=JBXDVAHQMNFCPZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331518   

TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331518(2-{8-[(3-Fluoropyridin-2-yl)(oxan-4-yl)methyl]-11-...)
Affinity DataIC50: <1nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331518(2-{8-[(3-Fluoropyridin-2-yl)(oxan-4-yl)methyl]-11-...)
Affinity DataIC50: <10nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent