BDBM331533 1-[11-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-[(R)-oxan-4-yl(phenyl)methyl]-3,8,10-triazatricyclo[7.4.0.02,7]trideca-1(9),2::US9725449, Example 377::US9725449, Example 379

SMILES CC(=O)c1cnc2c(c1)n([C@H](C1CCOCC1)c1ccccc1)c1nc(ccc21)-c1c(C)nnn1C

InChI Key InChIKey=XABREEJXVKOURU-MHZLTWQESA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 331533   

TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331533(1-[11-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-[(R)-oxan...)
Affinity DataIC50: <1nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 4 [1-477]/[333-460]/[44-168]/[44-460](Homo sapiens (Human))
Bristol-Myers Squibb

US Patent
LigandPNGBDBM331533(1-[11-(Dimethyl-1H-1,2,3-triazol-5-yl)-8-[(R)-oxan...)
Affinity DataIC50: <10nMAssay Description:The binding of compounds to bromodomain BRD4 (44-168), BRD4 (333-460), and BRD4 (1-477 or 44-460) was assessed using a time resolved fluorescent reso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent