BDBM332756 N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]pyridazin-3-yl]-2-[2-(trifluoromethyl)phenyl]acetamide::US10196382, Example 5::US10577354, Example 5

SMILES FC(F)(F)c1ccccc1CC(=O)Nc1ccc(nn1)N1CC[C@H](C1)Nc1cccnn1

InChI Key InChIKey=OTCWMVAEXPSBAB-OAHLLOKOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 332756   

TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM332756(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Affinity DataIC50:  30.6nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM332756(N-[6-[(3R)-3-(Pyridazin-3-ylamino)pyrrolidin-1-yl]...)
Affinity DataIC50:  30.6nMAssay Description:GLS Enzyme Potency AssayA Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent