BDBM33971 AEB071::Sotrastaurin::med.21724, Compound 190

SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1

InChI Key InChIKey=OAVGBZOFDPFGPJ-UHFFFAOYSA-N

Data  1 KI  26 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 28 hits for monomerid = 33971   

TargetCytochrome P450 3A4(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of CYP3A4-catalyzed midazolam 1'-hydroxylation in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PKCdelta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PKCepsilon by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCtheta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1.30nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.20nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.10nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1nMT: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2.10nMpH: 7.4 T: 2°CAssay Description:Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...More data for this Ligand-Target Pair
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of PKCeta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PKCalpha by scintillation proximity assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  50nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of PKCepsilon (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C eta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  6.10nMAssay Description:Inhibition of PKCeta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1nMAssay Description:Inhibition of PKCtheta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  81nMAssay Description:Inhibition of PKCtheta in human Jurkat T cells assessed as reduction in anti-CD3/CD28 antibody-induced T-cell activation by measuring decrease in IL-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Rattus norvegicus (rat))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  234nMAssay Description:Inhibition of PKCbeta in mouse B cells assessed as reduction in IgM-stimulated cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCbeta1 (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C delta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of PKCdelta (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PKCalpha (unknown origin) after 60 mins in presence of [gamma33P]ATP by scintillation proximity assayMore data for this Ligand-Target Pair
TargetOrf1a protein(MERS-CoV)
University of Bonn

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataEC50:  9.70E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C alpha type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of PKCbeta1 (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase D3(Homo sapiens (Human))
Mcgill University

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of PKCnu (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of PKCepsilon (unknown origin) by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of full length human PKCtheta using 5-FAM-RFARKGSLRQKNV-OH peptide substrate incubated for 30 mins by IMAP kinase assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProtein kinase C beta type(Homo sapiens (Human))
Novartis

LigandPNGBDBM33971(AEB071 | Sotrastaurin | med.21724, Compound 190)
Affinity DataIC50:  2nMAssay Description:Inhibition of PKCbeta-1 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed