BDBM340112 (S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phenyl)imidazo[1,5- a]pyrazin-3-yl)ethyl)-2- chloropyrimidine-4-carboxamide::US9758524, Example 105

SMILES CC(NC(=O)c1ccnc(Cl)n1)c1nc(-c2ccc(cc2)C(=O)Nc2ccccn2)c2c(N)nccn12

InChI Key InChIKey=VPLOEFPSLKKMCM-UHFFFAOYSA-N

Data  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340112   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340112((S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phe...)
Affinity DataEC50: <100nMAssay Description:Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340112((S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phe...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340112((S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phe...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340112((S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phe...)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340112((S)-N-(1-(8-amino-1-(4-(pyridin-2- ylcarbamoyl)phe...)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent