BDBM340181 (S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidazo[1,5-a]pyrazin-1-yl)- N-(5-ethylthiazol-2-yl)benzamide::US10239883, Example 117::US10934296, Example 117::US9758524, Example 117

SMILES CCc1cnc(NC(=O)c2ccc(cc2)-c2nc([C@@H]3CCCCN3C(=O)C=C)n3ccnc(N)c23)s1

InChI Key InChIKey=YFNIHFDNBYNSQG-IBGZPJMESA-N

Data  15 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 340181   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340181((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lck enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lck enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340181((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...)
Affinity DataEC50: >1.00E+3nMAssay Description:Src enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Src enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340181((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...)
Affinity DataEC50: >1.00E+3nMAssay Description:FynT enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.FynT enzyme ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340181((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...)
Affinity DataEC50: >1.00E+3nMAssay Description:Lyn enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Lyn enzyme (M...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM340181((S)-4-(3-(1-acryloylpiperidin-2-yl)-8- aminoimidaz...)
Affinity DataEC50: <10nMAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent