BDBM3429 6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-diamine::6-arylpyrido[2,3-d]pyrimidine deriv. 11

SMILES Nc1ncc2cc(c(N)nc2n1)-c1c(Cl)cccc1Cl

InChI Key InChIKey=YBGDFSNTQAQYRD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 3429   

TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3429(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Affinity DataIC50:  1.60E+4nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBiotin carboxylase(Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22...)
Achaogen

Curated by ChEMBL
LigandPNGBDBM3429(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant N-terminal His-tagged Pseudomonas aeruginosa PAO1 biotin carboxylase expressed in Escherichia coli Rosetta(DE3) pLysS cells...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3429(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Affinity DataIC50:  210nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Pfizer

LigandPNGBDBM3429(6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidine-2,7-...)
Affinity DataIC50:  3.00E+3nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed