BDBM346464 US10202378, Example 77::US10202378, Example 92a::US10202378, Example 92b::ethyl 4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate

SMILES CCOC(=O)c1c(C)[nH]c2c1c(cn(C)c2=O)C#CC(C)(O)C1CC1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 346464   

TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  49nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  243nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  1.09E+3nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  154nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  230nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346464(US10202378, Example 77 | US10202378, Example 92a |...)
Affinity DataIC50:  33.2nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent