BDBM346492 3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopropyl-3-hydroxy-but-1-ynyl)-2,6-dimethyl-1H-pyrrolo[2,3-c]pyridin-7-one::US10202378, Example 187::US10202378, Example 98a::US10202378, Example 98b

SMILES Cc1[nH]c2c(c1-c1nnc(o1)C(C)(C)C)c(cn(C)c2=O)C#CC(C)(O)C1CC1

InChI Key

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 346492   

TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  58nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  216nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  108nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  728nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  33.9nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346492(3-(5-tert-butyl-1,3,4-oxadiazol-2-yl)-4-(3-cyclopr...)
Affinity DataIC50:  227nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent