BDBM346540 (1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-but-1-ynyl)-2,6-dimethyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-3-carboxylate::US10202378, Example 144

SMILES CC(=O)N1CCC(COC(=O)c2c(C)[nH]c3c2c(cn(C)c3=O)C#CC(C)(C)O)CC1

InChI Key InChIKey=UGRQCDIAEZMYLC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 346540   

TargetTranscription initiation factor TFIID subunit 1 [1381-1497](Homo sapiens (human))
Genentech

US Patent
LigandPNGBDBM346540((1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-...)
Affinity DataIC50:  267nMAssay Description:His/Flag epitope tagged TAF1-BD11381-1497 was cloned, expressed, and purified to homogeneity. TAF1-BD binding and inhibition was assessed by monitori...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscription initiation factor TFIID subunit 1 [1504-1635](Homo sapiens (Human))
Genentech

US Patent
LigandPNGBDBM346540((1-acetyl-4-piperidyl)methyl4-(3-hydroxy-3-methyl-...)
Affinity DataIC50:  20.1nMAssay Description:His/Flag epitope tagged TAF1-BD21504-1635 was cloned, expressed, and purified to homogeneity. TAF1-BD2 binding and inhibition was assessed by monitor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent