BDBM349762 2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-[(1-ethyl-1H-imidazol-5-yl)methyl]-1H-benzimidazole-6-carboxylic acid::US10208019, Example 10A-32

SMILES CCn1cncc1Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(F)cc3F)n2)nc2ccc(cc12)C(O)=O

InChI Key InChIKey=IFXPEJAGKQFBER-UHFFFAOYSA-N

Data  1 KI  6 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 349762   

TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]PF-06883365 from FAP-tagged human GLP-1R expressed in CHO cells assessed as inhibition constant by radioligand binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  5nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  0.75nMAssay Description:Agonist activity at human GLP-1R expressed in CHO-K1 cells assessed as cAMP accumulation incubated for 30 mins in absence of BETP by plate reader met...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  250nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-1 cell assessed as induction of beta-arrestin 1 recruitment incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  610nMAssay Description:Agonist activity at human GLP-1R expressed in PathHunter CHO-K1 GLP1R beta-arrestin-2 cell assessed as induction of beta-arrestin 2 recruitment incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  0.470nMAssay Description:GLP-1R-mediated agonist activity was determined with a cell-based functional assay utilizing an HTRF (Homogeneous Time-Resolved Fluorescence) cAMP de...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlucagon-like peptide 1 receptor(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM349762(2-[(4-{6-[(2,4-difluorobenzyl)oxy]pyridin-2-yl}pip...)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at GLP-1R (unknown origin) expressed in candidate selection CHO cells assessed as cAMP accumulation incubated for 30 mins by plate r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB