BDBM350315 US10208064, Example 30

SMILES CC1=C(COC1=O)N1CCC2(CCN(CCc3ccc-4c(Cn5nnnc-45)c3)CC2)C1=O

InChI Key InChIKey=BSQXZHQSWBZCSM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 350315   

TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
University Of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM350315(US10208064, Example 30)
Affinity DataIC50:  6nMAssay Description:Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Wuxi Apptec (Shanghai)

US Patent
LigandPNGBDBM350315(US10208064, Example 30)
Affinity DataIC50:  6nMAssay Description:A Thallium Flux Assay was performed on the compounds of the Examples. This assay has been described previously; see, e.g., PCT Published Application ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent