BDBM350857 UNC2253A::US10004755, Compound UNC2253A::US9795606, B16

SMILES CCCCNc1ncc2c(cn(C3CC[C@H](O)CC3)c2n1)-c1ccc(cc1)C1(CC1)N1CCOCC1

InChI Key InChIKey=CREINZJAYXIGBI-SELCFAFUSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 350857   

TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350857(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Affinity DataIC50: <250nMAssay Description:The ectopic expression of Mer receptor tyrosine kinase (Mer) has been identified as a tumor cell survival gene product in Acute Lymphoblastic Leukemi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350857(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350857(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350857(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Affinity DataIC50:  245nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM350857(UNC2253A | US10004755, Compound UNC2253A | US97956...)
Affinity DataIC50:  157nMAssay Description:Inhibition constants of MerTK, Flt3, Tyro3 and Axl kinase activity by an active compound as described herein is determined at the Km for ATP using a ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent